None known

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Iboga root is very important in the initiation ceremonies of certain African tribes. The root bark can be eaten whole; or it can be crushed and ground then rolled into small balls; sometimes it is mixed with other ingredients; sometimes it is taken as a decoction of the crushed roots. The root is mainly employed as a hallucinogenic, a catalyst for spiritual discovery, and to seek information from ancestors and the spirit world, hence 'coming to terms with death'. Iboga is usually taken in large quantities in these ceremonies[299 ]. Iboga is also taken, usually in rather smaller quantities, as a means of divination to diagnose situations and also for therapeutic purposes[299 ]. The roots are considered to be aphrodisiac, febrifuge and tonic[299 ]. A decoction is often taken as a means of combating tiredness, hunger and thirst in situations such as hunting when it can be necessary to overcome physical stress[299 ]. A root macerate in palm wine is taken to soothe coughs, whilst the root decoction is drunk to treat urinary infections[299 ]. The pounded roots are also used in the curing ceremony (called 'zebola') for treating psychosomatic afflictions[299 ]. A decoction of the root is used for eye drops to treat conjunctivitis[299 ]. The leaves are considered to be anaesthetic and aphrodisiac[299 ]. The warmed leaves are rubbed on the gums to calm toothache[299 ]. The latex obtained from the plant is taken as an anthelmintic[299 ]. The active compounds, present in the root, root bark, stem bark, leaves and seeds of the plant, are indole alkaloids. About 20 have been identified so far[299 ]. The highest concentrations of alkaloids occur in the root bark (5 - 6%), followed by the roots (1 - 2.5%), stem bark (2%), seed (1%) and leaves (0.4 - 0.8%)[299 ]. Ibogaine (ibogan class) is the most important alkaloid present in all plant parts except the seeds. The main activities of ibogaine are on the central nervous system and on the cardiovascular system. At low doses, it exerts primarily a stimulant effect, increasing alertness and reducing fatigue, hunger and thirst. At higher doses, the primary effects are hallucinations, with unpleasant possible side effects such as anxiety and depression with fear or rage[299 ]. The peak effect is reached 1 - 3 hours after swallowing the drug; it subsides gradually, ending in complete insomnia and lethargy. These effects can last for 2 - 5 days. Apart from the psychological effects, the physical effects include tremor, light sensitivity, nausea and vomiting, loss of muscular coordination and prolonged and often painful muscle spasms, all in a dose-dependent way[299 ]. Toxic doses may produce convulsions, paralysis and death from respiratory arrest[299 ]. Most activities have been tested with purified ibogaine, but during initiation ceremonies powdered root bark is usually taken, which is more powerful as it contains a range of related alkaloids[299 ]. Ibogaine is a potent cholinesterase inhibitor, and the root extract is even 100 times stronger in its inhibitory effect because of the additional effects of the alkaloids tabernanthine, ibogamine and the more distantly related iboluteine. This property contributes to the anti-fatigue properties of ibogaine, and results from an increased sensitivity to adrenaline, bringing about a transient excited state of the sympathic nervous system[299 ]. Despite the reputation of iboga as an aphrodisiac, ibogaine did not produce a stimulation of sexual functions in various trials[299 ]. Tests have not shown ibogaine to have a significant analgesic effect[299 ]. Recent research indicates that ibogaine has a novel pharmacological mechanism of action, acting strongly on a variety of different receptors in the brain, resulting from complex interactions between neurotransmitter systems. There is no consensus yet on how ibogaine works precisely, but it is known to inhibit the re-uptake of the neurotransmitter serotonin, which can cause hallucinations[299 ]. However, the suggestion by laymen that ibogaine has considerable potential in the field of psychotherapy is premature. Research has shown that ibogaine is converted in the liver to noribogaine, which fills opiate receptors, thus eliminating withdrawal symptoms. Ibogaine also stimulates nicotinic receptors in the cerebellum, which contributes to modulating the dopamine reward circuit. At high doses though, ibogaine is toxic as it destroys neurons in the cerebellum[299 ]. There is evidence to suggest that ibogaine has considerable potential in treating addictions to heroin, cocaine, alcohol, nicotine, caffeine, amphetamine, desoxyephedrine or methadone, or combinations of these. Several methods to arrest the physiological and psychological aspects of dependency on drugs by using ibogaine have been patented in the United States. Treatments are claimed to be effective for 70 - 100% of the cases. However, the serious side effects of ibogaine make its use potentially harmful and additional clinical studies are needed to determine if and how it can be used safely[299 ].

Other Uses: None known

Special Uses